Time to first onset of HFSR/HFS by the Kaplan–Meier method during the SOLTI-0701 trial [47]. (A): Any grade event. (B): Grade 3 events.
aSafety population (patients who received any study drug[s]).
Abbreviations: CAP, capecitabine; HFS, hand–foot syndrome; HFSR, hand–foot skin reaction; PL, placebo; SOR, sorafenib.