Table 2.
Summary of ten hepatocellular carcinoma patients with severe cirrhosis who survived for > 1 year after proton beam therapy. CR: complete response; F: female; HBV: hepatitis B virus; HCV: hepatitis C virus; ICH: intracranial hemorrhage; IOIV: inside and outside of the irradiated volume; M: male; NED: no evidence of disease; OIV: outside of the irradiated volume; PD: progressive disease; PR: partial response; PS: performance status.
| Patient # | Age (years)/gender | PS | Etiology of cirrhosis | Child-Pugh score | Number of tumors | Tumor size (mm) | Total dose (Gy/fractions) | Tumor response | Pattern of failure | Follow-up (months) and status |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 67/M | 1 | HCV | 10 | Solitary | 50 | 84/24 | CR | Liver (OIV) | 63, dead of trauma |
| 2 | 54/M | 1 | HCV | 10 | Multiple | 25 | 84/24 | CR | Liver (OIV) | 56, dead of cancer |
| 3 | 68/M | 2 | HCV | 13 | Solitary | 35 | 72.5/19 | CR | None | 42, dead of liver failure |
| 4 | 66/F | 0 | Alcohol | 12 | Solitary | 30 | 72/16 | CR | Liver (OIV) | 37, dead of cancer |
| 5 | 63/F | 2 | HCV | 12 | Solitary | 60 | 67.5/15 | PR | Liver (OIV) | 17, dead of cancer |
| 6 | 60/F | 1 | HCV | 11 | Solitary | 40 | 72/16 | CR | Liver (OIV) | 57, dead of ICH |
| 7 | 52/M | 2 | HCV | 14 | Solitary | 35 | 50/10 | PD | Liver (OIV) | 19, dead of liver failure |
| 8 | 59/M | 1 | HCV | 10 | Solitary | 35 | 72/16 | CR | Liver (OIV) | 32, dead of cancer |
| 9 | 66/M | 1 | HCV | 11 | Solitary | 30 | 72/16 | CR | Liver (OIV) | 45, dead of liver failure |
| 10 | 53/M | 1 | HCV | 12 | Solitary | 35 | 50/10 | CR | None | 33, alive with NED |