Table 3.

Analysis of the Six Single Nucleotide Polymorphisms of Interest in Recurrent Pelvic Organ Prolapse Cases From Holland

Marker	Location	Compared to Utah POP Cases*	Compared to HapMap CEU (n=60)†	Compared to Utah-Matched iControls†		Minor Allele Frequency of Holland Cases	Minor Allele Frequency of Utah POP Cases
		Best P-value	Best P-value	Best P-value	OR
rs1455311	4q21.21	0.015	0.09§	0.198	0.72	0.14	0.34
rs1036819	8q24.22	1.2×10−3	0.086§	0.126	3.15	0.081	0.31
rs430794	9q22.2	0.892‡	0.278	0.328	0.59	0.291	0.13
rs8027714	15q11.2	6.4×10−3	0.588	0.085‡	13.57	0.061	0.26
rs1810636	20p13	0.012	0.416	0.588	1.2	0.36	0.57
rs2236479	21q22.3	1.4×10−3	0.616	0.029§	0.59	0.32	0.59

POP, pelvic organ prolapse; OR, odds ratio.

^*Genie was used for this analysis. We used 10,000 simulations for the analysis. Compared to the Utah POP cases, and the best P-value was considered the largest P-value.

^†Compared to the two control populations, the best P-value was considered the smallest P-value.

^‡Recessive model

^§Dominant model