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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Allergy Clin Immunol. 2011 Jan 31;127(3):576–586. doi: 10.1016/j.jaci.2010.12.1116

Figure 2. Microenvironmental signals initiate tolerogenic dendritic cell responses.

Figure 2

Oral tolerance depends on CD103+ mucosal dendritic cells encountering luminal antigens and transporting them to the mesenteric lymph nodes. This process requires CCR7 and is positively influenced by local factors such as retinoic acid, TGF-β, and IDO. CD103+ dendritic cells conditioned by these stimuli then interact with cognate T cells to actively suppress immune reactivity.