Table 8. Top 25 transcripts down-regulated in Nrl−/− retina compared to WT.
| Transcript | Gene ID | Gene name | WT FPKM | Nrl−/− FPKM | FC |
|---|---|---|---|---|---|
|
NM_145383 |
Rho |
Rhodopsin |
8135.4 |
1.7 |
−4803.93 |
|
NM_008140 |
Gnat1 |
Guanine nucleotide binding protein γ transducing activity polypeptide 1 |
4011.7 |
2 |
−2033.85 |
|
NM_001136074 |
Nrl |
Neural retina leucine zipper |
545 |
1.9 |
−284.05 |
|
NM_007723 |
Cnga1 |
Intracellular cGMP activated cation channel |
232.3 |
1 |
−229.13 |
|
NM_013708 |
Nr2e3 |
Nuclear receptor subfamily 2 group E member 3 |
237.2 |
1 |
−227.54 |
|
NM_144813 |
Slc24a1 |
Solute carrier family 24 member 1 (sodium-potassium-calcium exchanger 1) |
263.2 |
3.2 |
−81.57 |
|
NM_145963 |
Kcnj14 |
Potassium inwardly-rectifying channel subfamily J member 14 |
63.6 |
1.4 |
−44.02 |
|
NM_139292 |
Reep6 |
Receptor accessory protein 6 |
317.4 |
8.6 |
−36.76 |
|
NM_025491 |
Susd3 |
Sushi domain containing 3 |
58.1 |
1.7 |
−34.06 |
|
NM_011934 |
Esrrb
(isoform 1) |
Estrogen-related receptor β |
67.2 |
2.6 |
−26.17 |
|
NM_001007576 |
Gucy2f |
Guanylate cyclase 2f |
36.5 |
1.6 |
−22.78 |
|
NM_008806 |
Pde6b |
Phosphodiesterase 6B cGMP-specific rod β |
364.6 |
16.2 |
−22.32 |
|
NM_001195413 |
Cngb1 |
Cyclic nucleotide gated channel β 1 |
52.3 |
2.5 |
−21.11 |
|
NM_001160017 |
Gnb1
(isoform 3) |
Guanine nucleotide binding protein β polypeptide 1 |
487.8 |
24.4 |
−19.97 |
|
NM_008736 |
Nrl |
Neural retina leucine zipper |
20 |
1 |
−19.97 |
|
NM_008142 |
Gnb1
(isoform 1) |
Guanine nucleotide binding protein β polypeptide 1 |
349.7 |
17.9 |
−19.7 |
|
NM_007472 |
Aqp1 |
Aquaporin 1 |
42.5 |
2.2 |
−19.56 |
|
NM_001160016 |
Gnb1
(isoform 2) |
Guanine nucleotide binding protein β polypeptide 1 |
352.1 |
18.1 |
−19.29 |
|
NM_153803 |
Glb1l2 |
Galactosidase, β 1-like 2 |
55.7 |
3.5 |
−16.11 |
|
NM_001159500 |
Esrrb
(isoform 2) |
Estrogen-related receptor β |
22.5 |
1.5 |
−15.03 |
|
NM_172802 |
Fscn2 |
Fascin homolog 2, actin-bundling protein, retinal |
41.6 |
3 |
−14.03 |
|
NM_001033498 |
Gramd2 |
Member of the GRAM domain containing family |
20.3 |
1.4 |
−14.03 |
|
NM_027001 |
2610034M16Rik |
Unknown |
69.6 |
5.1 |
−13.64 |
|
NM_018865 |
Wisp1 |
WNT1 inducible signaling pathway protein |
17.8 |
1.4 |
−12.21 |
| NM_146086 | Pde6a | Rod photoreceptor cGMP phosphodiesterase α subunit | 433.5 | 35.8 | −12.13 |
Many of the genes down-regulated in Nrl−/− retina represent rod-specific transcripts, whereas upregulated genes include those associated with cone function and retinal remodeling.