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The effect of histones and activated enzymes post UV. P/Ph = phosphorylation, DePh = dephosphorylation, Ac = acetylation, Ub = ubiquitylation, Me = methylation. Upon UV-induced DNA damage, photoproducts are formed, triggering the ATM/ATR response, in turn phosphorylating P53 and activating P21, leading to cell cycle arrest. The amount of damage, as well as histone modifications and protein activation then determines the fate of the cell.
