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. 2011 Dec 7;6(12):e28144. doi: 10.1371/journal.pone.0028144

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Enrollment % DNA methylation (%MdCyt/total cytosine) is shown in green, DNA methylation level during the supplementation trial is shown in blue and DNA methylation level after the discontinuation of supplementation (withdrawal) is shown in red. A. Overall estimated mean %MdCyt and 95% Confidence Intervals (CI) were generated from a general linear model of repeated measure model (GLMRM) containing; folic acid dose, MTHFR genotype, age, BMI, enrollment RBC and time (0,1,3,6,9 months data) weighted to adjust for sampling. The model showed a significant interaction of folic acid dose and MTHFR genotype (P<0.001). B. Estimated mean %MdCyt and 95% CI were generated from a GLMRM stratified by folic acid dose; adjusting for MTHFR genotype age, BMI, enrollment RBC and time and weighted to adjust for sampling. C. Estimated mean %MdCyt and 95% CI were generated from a GLMRM stratified by MTHFR genotype; adjusting for folic acid dose, age, BMI, enrollment RBC and time and weighted to adjust for sampling. D. Estimated mean %MdCyt and 95% CI were generated from a GLMRM stratified by MTHFR genotype and folic acid dose; adjusting for age, BMI, enrollment RBC and time and weighted to adjust for sampling. * Significant difference compared to enrollment p<0.01 –^Ŧ Significant difference between the DNA methylation level at the end of the supplementation trial (6 months) and after the discontinuation of supplementation (9 months) p<0.01.