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Increased osteoblastic differentiation of P6 bone marrows of Mdm2−/− p53515C/515C mice in vitro. P6 whole bone marrows were allowed to grow for MSC colony formation. Mdm2−/− p53515C/515C (right) cells spontaneously differentiated into osteoblastic lineage as seen by red alkaline phosphatase activity while Mdm2+/− p53515C/515C (left) retained undifferentiated state.
