Table 2.
Regulation of EAPII expression
| Modulator | Function | EAPII changes | System/Models | References |
| knockdown HDAC8 (Histone deacetylases) | Transcription Modulator | ↓ | prostate cancer cells | 107 |
| FOXO3a | Transcription Modulator | ↑ | Apoptosis | 56 |
| HOXA9 knockdown | Transcription Modulator | ↓ | human AML cells | 108 |
| Myb | Transcription Modulator | ↑ | human monocytes | 109, 110 |
| Knockout DEAF1 | Transcription Modulator | ↑ | knockout mice | 111 |
| Knockdown MDM2 | Transcription Modulator | ↑ | cancer cell lines: A549, TOV-21G | 112 |
| Chronic antigen stimulation | ↑ | Regulatory T cell | 113 | |
| TRAIL | TNF-TNFR signaling | ↑ | T42 breast cancer cells | |
| IL-19 | Inflammatory response | 114 | ||
| IL-24 | ↑ | |||
| TRE M-1 activation | inflammatory responses | ↑ | 115 | |
| IL-4, GM-CSF | T cell differentiation/inflammatory response | ↑ | Monocyte to DC differentiation | 116 |
| LPS | Inflammatory mediator | ↓ | ATF3-/- mouse wild-type mouse | 101–103 |
| Insulin | Glucose metabolism | ↓ | 117 | |
| Knockout SIRT6 | glucose metabolism/histone deacetylase | ↓ | liver of SIR T6 knockout mice | 118 |
| Protocadherin LKC (PCDH24) | Contact inhibition | ↓ | Colon cancer cells | Na, 105 |
| α1antitrypsin (SERPINA1) | Serine protease inhibitor | ↓ | Transgenic mice | 119 |
| Knockdown UPF1 | eukaryotic surveillance | ↑ | 120 | |
| IFNγ | eukaryotic surveillance | ↑, NB-localized | 44 |
Data presented in this table are derived from NextBio (www.nextbio.com), which is based on multiple sources including NCBI GEO and EBI ArrayExpress. Original articles are reviewed and cited in the references if the array data have been published.