Table 4.
Estimates for full interaction model for liver attenuation1 (in Hounsfield Units)
| N=2719, number of families = 707 | |||
|---|---|---|---|
| Beta | SE | p-value | |
| Intercept | 10.12 | 1.96 | <.0001 |
| Sex (Male) | −2.29 | 1.03 | 0.0002 |
| Race (African American) | 7.65 | 2.06 | 0.03 |
| Age (yrs) | 0.07 | 0.02 | <.0001 |
| Alcohol (grams/wk) | −0.02 | 0.003 | <.0001 |
| Body Mass Index (kg/m2) | −0.14 | 0.07 | 0.06 |
| Abdominal visceral adipose (cm3) | −0.02 | 0.003 | <.0001 |
| Abdominal subcutaneous adipose (cm3) | 0.002 | 0.003 | 0.5 |
| Triglycerides (mg/dl) | −0.01 | 0.002 | <.0001 |
| HDL-Cholesterol (mg/dl) | −0.02 | 0.01 | 0.12 |
| HOMA-IR2 | −1.41 | 0.12 | <.0001 |
| Race* Sex (African American*Male) | 2.64 | 1.36 | 0.05 |
| Body Mass Index (kg/m2)*Sex (Male) | −0.34 | 0.07 | <.0001 |
| Triglycerides (mg/dl)*Race (African American) | 0.009 | 0.006 | 0.10 |
| HOMA-IR* Race (African American) | 0.82 | 0.17 | <.0001 |
| HOMA-IR* Sex (Male) | 0.93 | 0.14 | <.0001 |
| HOMA-IR* Race (African American) *Sex (Male) | −0.98 | 0.25 | 0.0001 |
1
Adjusted for phantom and center. A standardized phantom contains material that simulates water (expected HU=0) as well as increasing densities of calcium (50, 100 and 200 mg of calcium). These concurrent phantom measures at water density were used to adjust and standardize the liver attenuation measurements.
2
HOMA-IR (homeostasis model of insulin resistance)= (fasting serum glucose [mg/L]* fasting serum insulin [mU/L]/405)