Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Biol Psychiatry. 2011 Sep 3;71(5):467–473. doi: 10.1016/j.biopsych.2011.07.022

Table I.

Effects of varying doses of MPH on differing aspects of performance in the sustained attention task.

MPH Dose (mg/kg)
Veh 0.5 2.0 4.0 8.0
d′ 0.08 ± 0.07 0.29 ± 0.11** 0.53 ± 0.19** 0.17 ± 0.08 −0.72 ± 0.24**
Correct 0.01 ± 0.01 0.04 ± 0.01* 0.05 ± 0.02* 0.01 ± 0.01 −0.12 ± 0.05**
Pr. Hit 0.01 ± 0.02 −0.01 ± 0.01 0.07 ± 0.02* 0.02 ± 0.03 −0.21 ± 0.10*
Pr. FA 0.01 ± 0.02 −0.09 ± 0.02 0.03 ± 0.02ç −0.01 ± 0.02 0.040 ± 0.05

Shown are the effects of MPH on different aspects of sustained attention performance. expressed as a change from baseline performance levels. Shown are the mean ± SEM for: d′, proportion correct (Correct), probability of a hit (Pr. Hit) and probability of false alarms (Pr. FA). Vehicle data are an average from the 3 arms of testing (see Methods/Results). 2.0 mg/kg data are the average from the 2nd arm of testing in which this dose was used.

*

P < 0.05,

**

P < 0.01 vs. vehicle-treatment.