Table I.
Effects of varying doses of MPH on differing aspects of performance in the sustained attention task.
MPH Dose (mg/kg) | |||||
---|---|---|---|---|---|
Veh | 0.5 | 2.0 | 4.0 | 8.0 | |
d′ | 0.08 ± 0.07 | 0.29 ± 0.11** | 0.53 ± 0.19** | 0.17 ± 0.08 | −0.72 ± 0.24** |
Correct | 0.01 ± 0.01 | 0.04 ± 0.01* | 0.05 ± 0.02* | 0.01 ± 0.01 | −0.12 ± 0.05** |
Pr. Hit | 0.01 ± 0.02 | −0.01 ± 0.01 | 0.07 ± 0.02* | 0.02 ± 0.03 | −0.21 ± 0.10* |
Pr. FA | 0.01 ± 0.02 | −0.09 ± 0.02 | 0.03 ± 0.02ç | −0.01 ± 0.02 | 0.040 ± 0.05 |
Shown are the effects of MPH on different aspects of sustained attention performance. expressed as a change from baseline performance levels. Shown are the mean ± SEM for: d′, proportion correct (Correct), probability of a hit (Pr. Hit) and probability of false alarms (Pr. FA). Vehicle data are an average from the 3 arms of testing (see Methods/Results). 2.0 mg/kg data are the average from the 2nd arm of testing in which this dose was used.
P < 0.05,
P < 0.01 vs. vehicle-treatment.