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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Int J Gynecol Cancer. 2011 Dec;21(9):1613–1621. doi: 10.1097/IGC.0b013e318228f6da

Figure 3.

Figure 3

Representative cytotoxicity experiments (Effector to target: E/T; 25:1 and 50:1) using hRS7 against the Trop-2-positive cell line (i.e., EEC-ARK-1, upper panel) versus the Trop-2-negative cancer cell lines (i.e., EEC-ARK-2, middle panel and EEC-ARK-3, lower panel). High levels of hRS7 induced cytotoxicity were evident against EEC-ARK-1 primary cell line expressing high levels of Trop-2. In contrast, negligible cytotoxicity was detectable against EEC-ARK-2 and EEC-ARK-3 (i.e., low Trop-2 expressor cell lines). In all cell lines tested, no significant cytotoxicity was detected in the absence of hRS7 or in the presence of rituximab control mAb.