Table 3.

Clinical Factors and Abnormal Values in Pulmonary Function Tests

Outcome (Y)	Years after WLI (X1)			Pulmonary boost radiation (X2)			Pulmonary wedge resection (X3)
PFT parameter	OR	95% CI	P value	OR	95% CI	P value	OR	95% CI	P value
FVC	1.11	1.01–1.23	0.04	1.57	0.55–4.51	0.41	0.47	0.17–1.28	0.15
FEV1	1.12	1.01–1.24	0.03	1.8	0.61–5.34	0.29	0.59	0.21–1.64	0.31
FEV1/FVC	0.95	0.82–1.1	0.47	4.43	1.19–16.53	0.03	3.32	0.84–13.05	0.09
FEF25%–75%	1.06	0.97–1.17	0.22	3.83	1.56–9.39	0.005	1.85	0.75–4.55	0.19
TLC	1.13	1.02–1.24	0.02	1.31	0.5–3.48	0.59	1.21	0.47–3.09	0.7
FRC	0.88	0.68–1.14	0.33	8.43	0.49–145.14	0.15	0.95	0.11–8.11	0.96
RV	0.93	0.83–1.05	0.24	6.01	1.85–19.54	0.005	0.73	0.26–2.04	0.55
RV/TLC	0.96	0.88–1.05	0.41	4.17	1.76–9.88	0.002	0.31	0.13–0.77	0.002
DLCOcorr	1.02	0.93–1.12	0.71	0.63	0.25–1.58	0.33	0.94	0.38–2.32	0.89
DLCO/VA	0.97	0.81–1.17	0.77	3.08	0.51–18.51	0.23	0.78	0.13–4.78	0.79

Y, the response variable in the model; X₁, X_2,, and X₃, the independent variables in the model; CI, confidence interval; DLCO_corr, diffusion capacity of the lung for carbon monoxide corrected for hemoglobin; FEF_25%–75%, forced expiratory flow between 25% and 75% forced vital capacity; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; FRC, functional residual capacity; OR, odds ratio; PFT, pulmonary function test: RV, residual volume; TLC, total lung capacity; VA, alveolar volume; WLI, whole lung irradiation