Table 2.

Mean (+SD) and Median GABAergic neuroactive steroid serum concentrations and plasma cortisol concentrations in women as a function of depression status.

Neuroactive Steroid	Time Point	Never Depressed			Histories of Depression
		N	Mean (SD)	Median	N	Mean (SD)	Median
Progesterone (pg/ml)A, B
	Pre-progesterone	17	1.1 (1.7)	0.7	11	0.5 (0.6)	0.4
	Post-progesterone	17	83.4 (97.5)	46.6	11	25.4 (35.2)	1.7
3α,5α-THP (pg/ml)A, B
	Pre-progesterone	17	281.4 (191.0)	253.0	11	220.3 (186.7)	188.8
	Post-progesterone	17	4736.3 (3856.4)	3364.6	10	1759.9 (2126.5)	322.2
3α,5β-THP (pg/ml)A, B
	Pre-progesterone	17	1787.2 (4404.2)	78.6	11	1038.3 (1488.9)	295.3
	Post-progesterone	17	6572.5 (7533.7)	3454.3	11	3565.6 (2385.9)	4335.0
3α,5α-THDOC (pg/ml)
	Pre-progesterone		nd	nd		nd	nd
	Post-progesterone	14	204.9 (139.8)	171.0	8	125.4 (87.4)	93.7
3α,5β-THDOC (pg/ml)
	Pre-progesterone		nd	nd		nd	nd
	Post-progesterone	14	406.1 (392.8)	292.5	7	181.1 (98.4)	149.4
Pregnenolone (pg/ml)A
	Pre-progesterone	16	805.5 (529.8)	689.6	10	522.6 (235.0)	465.1
	Post-progesterone	16	861.3 (453.7)	799.0	10	495.8 (231.9)	463.7
Dehydroepiandros terone (DHEA) (pg/ml)A
	Pre-progesterone	17	2804.7 (4174.0)	1567.2	11	1048.6 (581.5)	861.2
	Post-progesterone	17	1000.3 (730.2)	847.0	11	582.4 (202.4)	546.0
3α,5α-A (pg/ml)A
	Pre-progesterone	16	276.5 (328.0)	185.6	10	165.0 (78.5)	176.1
	Post-progesterone	16	318.5 (293.8)	192.6	10	190.7 (144.9)	159.7
3α,5β-A (pg/ml)A
	Pre-progesterone	17	99.2 (214.3)	24.5	11	41.2 (28.9)	32.0
	Post-progesterone	17	168.8 (502.1)	27.0	11	36.1 (42.9)	18.2
Cortisol (ug/dl)C,D
	Baseline Rest	17	8.7 (3.2)	9.1	11	6.3 (1.9)	5.8
	Post-Stress	16	9.8 (3.3)	9.3	11	7.9 (2.7)	7.3

^APrior DEP < No Prior DEP at both pre- and post-progesterone time points; p < 0.01

^BPost-progesterone > Pre-progesterone concentrations; p < 0.01

^CPrior DEP < No Prior DEP at both rest and stress; p < 0.05

^DPost-Stress > Baseline Rest in both groups; p<.05

nd = not detectable in the majority of subjects