Table 2.

Multivariate analyses of factors associated with OS and RFS (n=396)

Variables	OS		RFS
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
HBsAg (positive vs. negative)	1.51(0.98–2.33)	0.063	n.a.
Child-Pugh score (B+C vs. A)	1.17(0.91–1.51)	0.218	n.a.
GGT (U/l) (>54 vs. ≤54)	1.35(0.99–1.83)	0.059	n.a.
AFP(ng/ml) (>20 vs. ≤20)	1.49(1.08–2.07)	0.015	n.a.
Tumor encapsulation (none vs. complete)	0.78(0.58–1.05)	0.097	n.a.
Tumor size (cm) (>5 vs. ≤5)	2.08(1.21–3.55)	0.008	n.a.
Tumor number (multiple vs. single)	1.40(0.81–2.40)	0.229	2.05(1.42–2.97)	0
Vascular invasion (yes vs. no)	1.20(0.69–2.08)	0.514	1.00(0.72–1.39)	0.994
TNM stage (II+III vs. I)	1.76(0.87–3.56)	0.117	1.39(0.96–2.00)	0.078
BCLC stage (B+C vs. 0+A)	0.64(0.37–1.10)	0.103	n.a.
Ptch1 (positive vs. negative)	n.a.		1.53(1.09–2.14)	0.013

Abbreviations: OS, overall survival; RFS, relapse-free survival; 95%CI, 95% confidence interval; GGT, gamma-glutamyl transpeptidase; BCLC, Barcelona Clinic Liver Cancer; Ptch1, protein patched were adopted for their prognostic significance by univariate analyses.