Table 3.

Univariate analyses of factors associated with survival and recurrence (n=396)

Variables	OS		TTR
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Sex (male vs. female)	1.12(0.72–1.74)	0.631	0.98(0.62–1.55)	0.92
Age, years (>50 vs. ≤50)	0.86(0.65–1.14)	0.293	1.07(0.78–1.45)	0.682
HBsAg (positive vs. negative)	1.73(1.14–2.64)	0.01	1.08(0.72–1.60)	0.722
HCV (positive vs. negative)	0.90(0.37–2.20)	0.822	1.13(0.46–2.76)	0.787
Child-Pugh score (B vs. A)	1.31(1.02–1.68)	0.033	0.89(0.67–1.18)	0.425
Liver cirrhosis (yes vs. no)	0.88(0.63–1.23)	0.448	1.07(0.75–1.51)	0.715
GGT (U/l) (>54 vs. ≤54)	1.62(1.20–2.18)	0.001	1.33(0.97–1.82)	0.078
ALT (U/l) (>75 vs. ≤75)	0.98(0.60–1.62)	0.944	0.74(0.41–1.34)	0.318
AFP(ng/ml) (>20 vs. ≤20)	1.82(1.32–2.50)	<0.001	1.26(0.91–1.75)	0.158
Tumor differentiation (III–IV vs. I–II)	1.14(0.85–1.53)	0.376	0.88(0.63–1.23)	0.441
Tumor encapsulation (none vs. complete)	0.59(0.45–0.78)	<0.001	0.88(0.65–1.21)	0.441
Tumor size (cm) (>5 vs. ≤5)	1.85(1.30–2.65)	0.001	0.88(0.59–1.31)	0.523
Tumor number (multiple vs. single)	2.30(1.68–3.15)	<0.001	2.10(1.47–3.00)	<0.001
Vascular invasion (yes vs. no)	1.97(1.45–2.67)	<0.001	1.51(1.06–2.14)	0.023
TNM stage (II+III vs. I)	2.34(1.76–3.11)	<0.001	1.82(1.33–2.50)	<0.001
BCLC stage (B+C vs. 0+A)	1.83(1.36–2.47)	<0.001	1.25(0.91–1.70)	0.166
Ptch1 (positive vs. negative)	1.06(0.77–1.46)	0.716	1.48(1.07–2.06)	0.019

Abbreviations: 95%CI, 95% confidence interval; RFS, Relapse-free survival; OS, overall survival. AFP, alpha-fetoprotein; GGT, gamma-glutamyl transpeptidase; ALT, alanine aminotransferase; TACE, transcatheter arterial chemoembolization; TNM, tumor-node-metastasis; BCLC, Barcelona Clinic Liver Cancer; Ptch1, protein patched homolog 1.

Univariate analysis, Cox proportional hazards regression model.