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. Author manuscript; available in PMC: 2012 Sep 10.
Published in final edited form as: AIDS. 2011 Sep 10;25(14):1711–1719. doi: 10.1097/QAD.0b013e328349c693

Table 3.

Effects of PSIP1 SNPs on disease progression in the CAPRISA AI 002 cohort, dominant model

Endpoint SNP Number SNPs on AIDS Progression
 Haplotype Number Haplotypes on AIDS Progression
RH 95% CI P RH 95% CI P
CD4 < 350 SNP1 5.98 2.27 – 5.82 0.04 HAP1 1.84 0.55- 6.12 0.77
CD4 < 350 SNP2 2.68 0.99 – 7.24 0.70 HAP2 0.84 0.19-3.77 0.21
CD4 < 350 SNP3 1.25 0.44 - 3.56 0.29 HAP3 0.00 0.00-0.00 0.99
CD4 < 350 SNP4 2.05 0.70 - 6.02 0.90 HAP4 5.41 1.92 -5.24 0.09
CD5 < 350 SNP5 1.74 0.50 – 6.05 0.71 HAP5 1.58 0.36 -7.49 0.66

Cox proportional hazards model (Cox model) was used to calculate the rate of CD4 decline to less that 350 cells/ml.

P-values uncorrected for multiple comparisons are shown.