Table 1.
Studies characteristics: Aims of the studies and timing of health-related quality of life recording
| Sudy | Study aim | Timing post op HRQL measures |
| McLarty et al[54] | Analysis of HRQL in long term survivors after surgery alone | A single assessment > 60 mo |
| De Boer et al[53] | Analysis of HRQL in long term survivors after transhiatal esophagectomy | A single assessment 3.5 (2.1-5.4) yr |
| Headrick et al[49] | Analysis of HRQL in long term survivors after esophagectomy for HGD or adenocarcinoma | A single assessment 5.3 (0.5-9) yr |
| Cense et al[52] | Analysis of HRQL in long term survivors after esophagocolonplasty | A single assessment 35 (7-97) mo |
| Moraca et al[50] | Analysis of HRQL in long term survivors after esophagectomy for HGD or Tis | A single assessment 4.9 (0.5-12) yr |
| Reynolds et al[55] | Comparison between HRQL after neoadjuvant CT-RT+ surgery and after surgery alone | Baseline, after CT-RT, 3, 6, 9, 12 mo po |
| Avery et al[56] | Comparison between HRQL after neoadjuvant CT-RT+ surgery and after definitive CT-RT | 1, 5, 3, 6, 9 mo |
| van Meerten et al[57] | Analysis of HRQL after neoadjuvant CT-RT + surgery | Baseline, after CT-RT, 3, 6, 9, 12 mo po |
| Wang et al[59] | Comparison between open surgery and minimally invasive esophagectomy | 2, 4, 12, 24 wk |
| Parameswaran et al[58] | Analysis of HRQL after minimally invasive esophagectomy | 6, 12 mo |
| Viklund et al[45] | Analysis of HRQL predictors after esophagectomy for cancer (type of recstruction) | A single assessment 6 mo |
| Rutegard et al[46] | Analysis of HRQL predictors after esophagectomy for cancer (type of recstruction) | A single assessment 6 mo |
| Rutegard et al[47] | Analysis of HRQL predictors after esophagectomy for cancer (type of recstruction) | A single assessment 6 mo |
| Olsen et al[60] | Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery) | A single assessmentat 24 mo po |
| Lagergren et al[61] | Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery) | Baseline and 36 mo |
| Djarv et al[62] | Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery) | 6, 36 mo |
| Courrech Staal et al[63] | Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery) | A single assessment at 54 (16–162) mo |
| Blazeby et al[64] | Comparison between HRQL after surgery alone and after palliative RT | A single assessment 16 (10-24) wk |
| Ariga et al[65] | Comparison between surgery alone and definitive CT-RT + salvage surgery | A single assessment 24 mo |
| Schneider et al[48] | Comparison between HRQL after emergency and elective esophagectomy | 1 wk and 9 mo |
| Rosmolen et al[51] | Comparison between HRQL after endoscopical ablation and esophagectomy for early Barrett’s neoplasms | A single assessment at 24 (17–35) mo |
The 21 studies included in the analysis are listed according their aim and then chronologically. HRQL: Health-related quality of life; HGD: High grade dysplasia; CT-RT: Chemotherapy-radiotherapy; op: Operative; po: Post-operative.