Table 3.
Patient characteristics
| Study | Patients | Median/1mean age (range) | Recruitment period | Adenocarcinoma | Squamous cell carcinoma | Tis/ HGD/ pCR | Stage I | Stage II | Stage III | Stage IV | Lower esophagus or cardias | Medium or upper esophagus | Mean/1median follow up (mo) | Esophago-gastroplasty | Esophago-colonplasty | Esophago-jejeunoplasty | Neoadjuvant treatment | Adjuvant RT/CT/CT+RT |
| McLarty et al[54] | 107 | 62 (30-81) | 1972-1990 | 72 | 28 | 0 | 34 | 73 | 0 | 62 | 45 | > 60 | 99 | 3 | 4 | 0 | 9 | |
| De Boer et al[53] | 35 | 66.41 (42-87) | 1993-1996 | 27 | 6 | 2 | 14 | 1 | 18 | 32 | 3 | > 24 | 35 | 0 | 0 | |||
| Headrick et al[49] | 54 | 64 (36-83) | 1991-1997 | 53 | 1 | 5/35 | 7 | 2 | 5 | 54 | 0 | 63.61 (6-108) | ||||||
| Cense et al[52] | 14 | 69.9 (51-81) ECP, 66.4 (42-87) EGP | 1993-2002 | 6 | 7 | 1 | 8 | 3 | 2 | 10 | 3 | 35 (7-97) | 0 | 14 | ||||
| Moraca et al[50] | 36 | 661 (43-88) | 1991-2003 | 35 | 0 | 12/24 | 12 | 58.8 (6-144) | 36 | 0 | 0 | 0 | 0 | |||||
| Subtotal | 246 (14-107) | 193 | 42 | 3 | 75 | 79 | 25 | 0 | 158 | 51 | 0 | 170 | 17 | 4 | 0 | 9 | ||
| Reynolds et al[55] | 107 | 61 (29-79) | 1999-2004 | 34 | 68 | 25 | 63 | 83 | 3 | 3 | 87 | 87 | ||||||
| Avery et al[56] | 94 | 62.41 | 2000-2004 | 64 | 17 | 14 | 67 | 1.5 | 69 | 69 | ||||||||
| van Meerten et al[57] | 54 | 59 (40-75) | 2001-2004 | 41 | 12 | 13 | 12 | 6 | 16 | 5 | 49 | 5 | 3 | 54 | 54 | |||
| Subtotal | 255 (54-107) | 239 | 97 | 13 | 37 | 83 | 166 | 8 | 49 | 5 | 7.5 | 0 | 0 | 0 | 210 | 210 | ||
| Wang et al[59] | 56 | 60.7 ± 9.3 VATS 58.2 ± 11.5 open | 2007-2008 | 3 | 52 | 11 | 37 | 8 | 10 | 46 | 6 | 56 | 0 | |||||
| Parameswaran et al[58] | 62 | 67 (49-80) | 2005-2007 | 57 | 5 | 3 | 7 | 21 | 27 | 4 | 12 ± 0.5 | 62 | 48 | |||||
| Subtotal | 118 (56-62) | 60 | 57 | 3 | 18 | 58 | 35 | 4 | 10 | 46 | 6 | 118 | 0 | 0 | 48 | 0 | ||
| Viklund et al[45] | 64 (34-84)1 | 2001-2003 | 6 | 16 | ||||||||||||||
| Rutegard et al[46] | 91 pts < 60, 127 pts 60-70, 137 pts >70 | 2001-2005 | 6 | 37 | ||||||||||||||
| Rutegard et al[47] | 355 | 91 pts < 60, 127 pts 60-70, 137 pts > 70 | 2001-2005 | 271 | 84 | 81 | 120 | 133 | 18 | 302 | 53 | 6 | 37 | |||||
| Subtotal | 355 | |||||||||||||||||
| Olsen et al[60] | 18 | 62.5 (20-76) | 1997-2001 | 3 | 5 | 1 | 9 | 24 | 13 | 4 | 1 | 8 | 8 | |||||
| Lagergren et al[61] | 47 | 63 (44-79) | 2000-2003 | 35 | 9 | 8 | 10 | 23 | 6 | 23 | 24 | > 36 | 29 | |||||
| Djarv et al[62] | 87 | 27 pts < 60, 28 pts 60-70, 32 pts > 70 | 2001-2007 | 68 | 19 | 34 | 36 | 13 | 3 | 75 | 12 | > 36 | 69 | 2 | 16 | |||
| Courrech Staal et al[63] | 36 | 2009 | 22 | 14 | 0 | 4 | 12 | 12 | 8 | 28 | 8 | 54 (range, 16–162) | 21 | |||||
| Subtotal | 188 (18-87) | 125 | 42 | 8 | 53 | 72 | 40 | 11 | 126 | 44 | 82 | 6 | 17 | 58 | 8 | |||
| Blazeby et al[64] | 33 | 64 (62-76) | 1993-1994 | 19 | 14 | 4 (2.5-6) | 0 | |||||||||||
| Ariga et al[65] | 48 | 65.5 (46-78) | 2001-2004 | 0 | 48 | 10 | 15 | 23 | 20 | 28 | 41.2 (95% CI: 35.1-47.2) | |||||||
| Schneider et al[48] | 12 | 59 | 2001-2005 | 1 | 11 | > 9 | 10 | 2 | ||||||||||
| Rosmolen et al[51] | 27 | 63.0 (9.5) | 2001-2005 | 27 | 0 | 2 | 19 | 6 | 24 (IQR 17 – 35) | 23 | 4 | 0 | 0 | |||||
| Subtotal | 120 (12-48) | 47 | 73 | 2 | 29 | 21 | 23 | 0 | 20 | 28 | 33 | 6 | 0 | 0 | 0 | |||
The 21 studies included in the analysis are listed according their aim and then chronologically. pts: Patients; ECP: Esophagocolonplasty; EGP: Esophagogastroplasty; VATS: Video assisted thoracoscopy; CI: Confidence interval; HGD: High grade dysplasia; pCR: Pathological complete response; RT: Radiotherapy; CT: Chemotherapy; IQR: Interquartile range.