Table 3.
Sensitivity and specificity of non-invasive tests in relation to invasive tests and a gold standard in 280 patients from Anchorage, Alaska, 1999-20001
| Test type 1 | Test type 2 | Sensitivity | Specificity | NPV2 | PPV2 | Accuracy |
| 13C-UBT3vs | Histology | 93.6% (131/140) | 82.9% (116/140) | 92.8% (116/125) | 84.5% (131/155) | 88.2% (247/280) |
| Histology and CLO test®4 | 96.8% (121/125) | 78.1% (121/155) | 96.8% (121/125) | 78.1% (121/155) | 86.4% (242/280) | |
| Culture | 93.1% (134/144) | 84.6% (115/136) | 92.0% (115/125) | 86.5% (134/155) | 89.0% (249/280) | |
| Culture and CLO test® | 94.6% (123/130) | 78.7% (118/150) | 94.4% (118/125) | 79.4% (123/155) | 86.1% (241/280) | |
| Gold standard | 93.3% (139/149) | 87.8% (115/131) | 92.0% (115/125) | 89.7% (139/155) | 90.7% (254/280) | |
| Anti-HP IgG vs | Histology | 91.5% (118/129) | 61.8% (81/131) | 88.0% (81/92) | 70.2% (118/168) | 76.5% (199/260) |
| Histology and CLO test® | 93.1% (108/116) | 58.3% (84/144) | 91.3% (84/92) | 64.3% (108/168) | 73.8% (192/260) | |
| Culture | 93.3% (126/135) | 66.4% (83/125) | 90.2% (83/92) | 75.0% (126/168) | 80.3% (209/260) | |
| Culture and CLO test® | 93.4% (113/121) | 60.4% (84/139) | 91.3% (84/92) | 67.3% (113/168) | 75.8% (197/260) | |
| Gold standard | 92.9% (130/140) | 68.3% (82/120) | 89.1% (82/92) | 77.4% (130/168) | 81.5% (212/260) | |
| Anti-HP IgG vs | 13C-UBT | 91.0% (131/144) | 68.1% (79/116) | 85.9% (79//92) | 78.0% (131/168) | 80.8% (210/260) |
| Histology vs | Culture | 87.5% (126/144) | 89.7% (122/136) | 87.1% (122/140) | 90.0% (126/140) | 88.6% (248/280) |
| CLO test®vs | Histology | 89.3% (125/140) | 90.7% (127/140) | 89.4% (127/142) | 90.6% (125/138) | 90.1% (252/280) |
| CLO test®vs | Culture | 90.3% (130/144) | 94.1% (128/136) | 90.1% (128/142) | 94.2% (130/138) | 92.1% (258/280) |
1The gold standard was a positive Helicobacter pylori (H. pylori) test by culture or, in the case of a negative culture result, a positive histology result and a positive campylobacter-like organism (CLO) test.
2
Negative and positive predictive value (NPV and PPV).
13
C urea breath test (UBT)3, BreathTekTM, Meretek Diagnostics Inc. 4Rapid urease test, Ballard Medical Products. Anti-HP IgG: Antibodies to H. pylori immunoglobulin G.