Table 4.
Among Helicobacter pylori positive persons (according to the gold standard, n = 149), the relationship between antibodies to Helicobacter pylori immunoglobulin G optical density and delta over baseline for the 13C urea breath test and demographics, histology and endoscopy outcomes
| Factors | Anti-HP IgG OD1 | 13C-UBT DOB2 | ||||
| High, OD ≥ 1.1, (n = 76) | Low, OD < 1.1, (n = 73) | P value | High, ≥ 10%, (n = 71) | Low, < 10%, (n = 78) | P value | |
| Demographics | ||||||
| % Male | 54% (41) | 19% (14) | < 0.0001 | 31% (22) | 42% (33) | 0.15 |
| % ≥ 50 years of age | 33% (25) | 40% (29) | 0.39 | 53% (27) | 29% (27) | 0.002 |
| Factors from histological examination | ||||||
| % Intestinal metaplasia | 11% (8) | 12% (9) | 0.73 | 8% (6) | 14% (11) | 0.27 |
| % Acute gastritis | 55% (42) | 49% (36) | 0.47 | 49% (35) | 55% (43) | 0.48 |
| % Chronic gastritis | 93% (71) | 77% (56) | 0.003 | 86% (61) | 85% (66) | 0.82 |
| % Numerous H. pylori | 42% (32) | 36% (26) | 0.42 | 54% (38) | 26% (20) | 0.0005 |
| Endoscopic factors | ||||||
| % Ulcer | 10% (7) | 11% (8) | 0.76 | 9% (6) | 12% (9) | 0.57 |
| % Gastritis | 58% (42) | 40% (29) | 0.03 | 49% (34) | 48% (37) | 0.88 |
1
Antibodies to Helicobacter pylori (H. pylori) immunoglobulin G optical density (anti-HP IgG OD) was associated with male gender [P < 0.0001, odds ratio (OR) = 6.2] and chronic gastritis (P = 0.003, OR = 5.8) on multivariate analysis.
2
Delta over baseline (DOB) from 13C urea breath test (UBT) test was associated with numerous H. pylori (P = 0.0005, OR = 3.6) and older age (P = 0.01, OR = 2.5) on multivariate analysis.