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. Author manuscript; available in PMC: 2012 Oct 20.
Published in final edited form as: N Engl J Med. 2011 Oct 20;365(16):1492–1501. doi: 10.1056/NEJMoa1014181

Table 2.

Mortality, AIDS defining illness and mortality combined and immune reconstitution inflammatory syndrome rates, stratified according to baseline CD4+ cell count.

CD4+ count Early Integrated Therapy Late Integrated Therapy Incidence Rate
Ratio
(95% CI)*		 P
Value
No. of
patients		 No. of
Person-
Yr		 No. of
events		 Event Rate /
100 Person-
Yr (95% CI)		 No. of
patients		 No. of
Person-
Yr		 No. of
events		 Event Rate /
100 Person-
Yr (95% CI)
Mortality
All patients 214 261.7 15 5.7 (3.2 – 9.5) 215 250.9 15 6.0 (3.3 – 9.9) 0.96 (0.44 – 2.10) 0.91
<50 cells/mm3 37 47.5 3 6.3 (1.3 – 18.5) 35 43.1 7 16.2 (6.5 – 33.5) 0.39 (0.06 – 1.70) 0.17
≥50 cells/mm3 177 214.2 12 5.6 (2.9 – 9.8) 180 207.8 8 3.8 (1.7 – 7.6) 1.46 (0.55 – 4.10) 0.41
AIDS defining illness or death
All patients 214 259.4 18 6.9 (4.1 – 11.0) 215 244.2 19 7.8 (4.7 – 12.2) 0.89 (0.44 – 1.79) 0.73
<50 cells/mm3 37 46.8 4 8.5 (2.3 – 21.9) 35 38.0 10 26.3 (12.6 – 48.4) 0.32 (0.07 – 1.13) 0.06
≥50 cells/mm3 177 212.6 14 6.6 (3.6 – 11.0) 180 206.2 9 4.4 (2.0 – 8.3) 1.51 (0.61 – 3.95) 0.34
Immune Reconstitution Inflammatory Syndrome
All patients 214 213.4 43 20.1 (14.6 – 27.1) 215 233.6 18 7.7 (4.6 – 12.2) 2.62 (1.48 – 4.82) <0.001
<50 cells/mm3 37 29.9 14 46.8 (25.6 – 78.4) 35 40.3 4 9.9 (2.7 – 25.4) 4.71 (1.48 – 19.64) 0.01
≥50 cells/mm3 177 183.4 29 15.8 (10.6 – 22.7) 180 193.3 14 7.2 (4.0 – 12.1) 2.18 (1.12 – 4.47) 0.02