Table 4.
PiB PET Studies in MCI: Prevalence and Conversion
Reference | Number of MCI Subjects | Number of Converters | Duration (years) |
||||
---|---|---|---|---|---|---|---|
Total | PiB(+) | PiB(−) | Total | PiB(+) | PiB(−) | ||
Cross-Sectional | |||||||
(Rowe et al., 2010) | 57 | 39 | 18 | n/a | n/a | n/a | n/a |
(Devanand et al., 2010) | 24 | 7 | 17 | n/a | n/a | n/a | n/a |
(Tolboom et al., 2009d) | 13 | 5 | 8 | n/a | n/a | n/a | n/a |
(Lowe et al., 2009) | 23 | 9 | 14 | n/a | n/a | n/a | n/a |
Longitudinal | |||||||
(Forsberg et al., 2008) | 21 | 11 | 10 | 7 | 7 | 0 | 0.7±0.5 |
(Koivunen et al., 2008) | 15 | 13 | 2 | 6 | 6 | 0 | 2 |
(Wolk et al., 2009) | 23 | 13 | 10 | 5 | 5 | 0 | 1.8±1.3 |
(Okello et al., 2009b) | 31 | 17 | 14 | 15 | 14 | 1 | 1 to 3 |
(Jagust et al., 2010)a | 65 | 47 | 18 | 24 | 21 | 3 | 1–2 |
Total Longitudinal | 155 | 101 | 54 | 57 | 53 | 4 | |
Total All Studiesb | 272 | 161 | 111 |
ADNI data.
Only the most recent report from each research group was used to avoid subjects being reported multiples times. When only graphical data were published without mean ± SD, these values were derived from the graph. If specific assignment of PiB-positivity was not made in the report, visual interpretation of graphic data using 1.5 SUVR or an equivalent measure in other units was performed.