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Alignment of residues contributing to the aromatic box in the Cys-loop receptor family
| Receptor | A | B | C | D | |
|---|---|---|---|---|---|
| nACh | Y93 | W149 | Y190 | Y198 | W55 |
| 5-HT3 | E129 | W183 | F226 | Y234 | W90 |
| MOD-1 | C120 | Y180 | Y221 | W226 | F83 |
| GABAC | F138 | Y198 | Y241 | Y247 | Y102 |
| GABAA | Y97 | Y157 | F200 | Y205 | F65 |
| RDL | F146 | F206 | L249 | Y254 | Y109 |
| Gly | F99 | F159 | Y202 | F207 | F63 |
Appropriate binding segments are labeled accordingly. Residues in bold have been shown to be involved in cation-π interactions.
