Table 5.

Trend p-values for associations between genes located on 9p21 and CMM, number of nevi, skin complexion, and tanning ability using gene-based analysis¹.

Gene	#SNP	CMM	Nevi	Skin complexion	Tanning
IFNB1	23	0.79	0.97	0.25	0.02
IFNW1	12	0.97	0.50	0.49	0.002
IFNA21	4	0.51	0.06	0.48	0.27
IFNA10	2	0.20	0.07	0.32	0.41
IFNA16	2	0.55	0.09	0.59	0.75
IFNA17	1	0.14	0.12	0.60	0.43
IFNA14	3	0.24	0.39	0.52	0.32
IFNA5	3	0.29	0.18	0.66	0.50
KLHL9	2	0.40	0.71	0.20	0.63
IFNA6	4	0.21	0.62	0.55	0.94
IFNA2	7	0.36	0.72	0.28	0.72
IFNA8	11	0.19	0.68	0.14	0.54
IFNA1	7	0.96	0.38	0.95	0.34
IFNE1	5	0.33	0.92	0.84	0.79
MTAP	17	0.85	0.06	0.26	1.00
CDKN2A	25	0.79	0.01	0.90	0.81
CDKN2B	17	0.99	0.72	0.30	0.03
ANRIL	15	0.68	0.24	0.12	0.04
TUSC1	12	0.02	0.44	0.50	0.62
PLAA	14	0.99	0.89	0.05	0.91
IFNK	9	0.38	0.45	0.95	0.15
ACO1	35	0.0004	0.90	0.56	0.0002

^1.p-values were computed using rank-truncated test statistics and a permutation-based sampling procedure (20,000 permutations).