Table 4.

Areas of Significant Interaction between Condition (Combat Slides and Sounds versus Neutral Slides and Sounds) and PTSD Diagnosis in Vietnam Combat Veterans with and without PTSD

Areas with Patterns of Increased Blood Flow in PTSD and Decreased Blood Flow in non-PTSDa					Areas with Patterns of Increased Blood Flow in non-PTSD and Decreased Blood Flow in PTSDb
Z score	Talairach coordinates				Z score	Talairach coordinates
	x	y	z	Brain region		x	y	z	Brain region
3.36	−40	−28	28	L. inferior parietal Louule (40)	4.12	8	20	−12	Medial prefrontal (subcallosal gyrus) (25)
3.22	8	−56	0	R. lingual gyrus (parahippocampus) (19)	3.32	−8	18	−12
3.17	8	−40	−20	R. cerebellum/pons/parahippocampus	3.24	44	−66	12	R. middle temporal gyrus (39)
3.17	2	−12	32	Mid cingulate (23)	3.23	−56	−32	−4	L. middle temporal gyrus (21)
3.00	−46	−4	24	L. precentral gyrus (motor cortex) (6)	2.99	−12	−22	12	L. thalamus

Z score > 3.00; p < .001.

^aSignificance of interaction term could be related to either increases in PTSD or decreases in non-PTSD, or a combination of the two.

^bSignificance of interaction term could be related to either increases in non-PTSD or decreases in PTSD, or a combination of the two (see Figure 1).

Other areas of interaction significant at the p < .01 level included: (greater increase in PTSD) cerebellum (Z score = 2.64; x = −20, y = −66, z = −28), (greater decrease in non-PTSD) right superior temporal gyrus (Z score = 2.54; x = 60, y = −34, z = 12), (greater increase in non-PTSD) right anterior cingulate (Z score 2.83; x = 12, y = 44, z = 12), (greater increase in non-PTSD) left visual association cortex (19) (Z score 2.37; x = −30, y = −88, z = 16).