Table 3.
Maternal body composition and blood analyses at the end of the experiment
| LF (n = 5–10) | HF (n = 5–11) | DR3 (n = 6–11) | |
|---|---|---|---|
| Body weight, g | 25.23 ± 0.69 | 44.81 ± 2.67* | 29.13 ± 0.72# |
| Fat mass, %body weight | 18.79 ± 1.08 | 48.05 ± 2.41* | 21.98 ± 1.10# |
| Lean mass, %body weight | 77.16 ± 0.99 | 50.23 ± 2.30* | 75.04 ± 1.10# |
| Glucose, mg/dl | 136 ± 3 | 150 ± 6 | 148 ± 3 |
| Hb A1c, % | 4.1 ± 0.04 | 4.2 ± 0.09 | 4.2 ± 0.06 |
| Insulin, ng/ml | 0.30 ± 0.04 | 0.50 ± 0.05 | 0.43 ± 0.10 |
| Serum TG, mg/dl | 37.55 ± 4.02 | 37.14 ± 3.16 | 29.89 ± 2.50 |
| Hepatic Il1b (relative expression) | 1.000 ± 0.142 | 0.912 ± 0.186 | 1.668 ± 0.337 |
| Hepatic Il6 (relative expression) | 1.000 ± 0.187 | 1.355 ± 0.280 | 2.009 ± 0.363 |
| Hepatic Tnf (relative expression) | 1.000 ± 0.090 | 0.764 ± 0.113 | 1.305 ± 0.359 |
Values are means ± SE. TG, triglycerides. Dams were euthanized after 28–31 wk on their respective diets. Hepatic gene expression was normalized to β-actin.
*
P < 0.001 vs. LF dams;
#
P < 0.001 vs. HF dams.