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. 2011 Aug 17;301(6):C1325–C1343. doi: 10.1152/ajpcell.00054.2011

Fig. 5.

Fig. 5.

Human RhAG F65S mediates increased lithium uptake compared with wild-type RhAG. A: lithium uptake by oocytes previously injected with water or with cRNA encoding wild-type RhAG or RhAG mutant F65S (10 ng cRNA). Values are means ± SE for (n) oocytes. *P < 0.05 (gray bar) compared with wild-type RhAG (Dunnett's t-test). B: lithium uptake by oocytes expressing wild-type RhAG was increased in the presence of coexpressed GPB (1 ng injected cRNA of each type). Values are means ± SE (n) oocytes. *P < 0.05 (gray bar) compared with wild-type RhAG (Dunnett's t-test). C: coexpression of wild-type AE1 with wild-type RhAG did not increase RhAG-mediated lithium uptake (1 ng cRNA). Ouabain (0.5 mM) and bumetanide (5 μM) were present in all experiments. P > 0.05 compared with wild-type RhAG (Dunnett's t-test).