Fig. 8.

Pharmacological profiles of Rb⁺ influx and lithium uptake into oocytes expressing wild-type RhAG or RhAG F65S. A: effects of inhibitors on ⁸⁶Rb⁺ influx into Xenopus oocytes expressing wild-type RhAG. B: effects of inhibitors on ⁸⁶Rb⁺ influx into oocytes expressing RhAG F65S. C: effects of inhibitors on Li⁺ influx into oocytes expressing wild-type RhAG. D: effects of inhibitors on Li⁺ influx into oocytes expressing RhAG F65S. Values are means ± SE for (n) oocytes. Inhibitor concentrations were DIDS (500 μM), amiloride (1 mM), NH₄Cl (5 mM), methylammonium (MA; 5 mM), phloretin (500 μM), and Gd³⁺ (50 μM). Ouabain (0.5 mM) and bumetanide (5 μM) were present in all experiments. *P < 0.05 (gray bar) compared with absence of inhibitor (Dunnett's t-test). Inhibitor effects on uninjected oocytes are summarized in results.