Skip to main content
. 2011 Aug 31;301(6):C1296–C1306. doi: 10.1152/ajpcell.00237.2011

Fig. 1.

Fig. 1.

Inhibitors of extracellular signal-regulated kinase (ERK) activation eliminate inhibition of HCO3 absorption by bath lipopolysaccharide (LPS). Medullary thick ascending limbs (MTAL) from Sprague-Dawley rats and C57BL/6J mice were isolated and perfused in vitro. Tubules were studied in control solution (A and C) or bathed with 15 μM U0126 or 15 μM PD98059 (B and D), and then LPS (500 ng/ml) was added to and removed from the bath solution. Absolute rates of HCO3 absorption (JHCO3) were measured as described in methods. Data points are average values for single tubules. Lines connect paired measurements made in the same tubule. P values are for paired t-test. NS, not significant. Mean values are given in results.