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. 2011 Sep 30;301(6):H2466–H2472. doi: 10.1152/ajpheart.00729.2011

Fig. 4.

Fig. 4.

Effect of reduced extraluminal O2 tension on dilation of isolated skeletal muscle arterioles perfused with erythrocytes (RBCs). Isolated arterioles were exposed to either extraluminal normoxia (room air, Po2 = 147 ± 2 mmHg) or reduced O2 tension (Po2 = 17 ± 2 mmHg) and perfused with buffer containing well-oxygenated erythrocytes from either healthy humans (n = 5) or humans with DM2 (n = 10, HbA1c = 8.3 ± 0.8). In some studies type 2 diabetes erythrocytes were pretreated with cilostazol (Cilo) at a concentration of either 10 μM (n = 3) or 100 μM (n = 7). Values are means ± SE. *Different from value during extraluminal normoxia (P < 0.05); †different from vessels perfused with type 2 diabetes erythrocytes in the absence of Cilo (P < 0.05).