Table 1.
Baseline data for WT, A2AKO, A2BKO, and A2A/2BDKO mouse hearts
| WT | A2AKO | A2BKO | A2A/2BDKO | |
|---|---|---|---|---|
| No. of mice | 30 | 12 | 29 | 15 |
| Body weight, g | 25 ± 0.6 | 25 ± 1.2 | 23.8 ± 0.6* | 24.7 ± 1.1 |
| Heart weight, g | 0.1 | 0.1 | 0.1 | 0.1 |
| Heart weight-to-body weight ratio, % | 0.5 ± 0.4 | 0.4 | 0.4 ± 0.1 | 0.4 |
| Coronary flow, ml•min−1•g−1 | 15.2 ± 0.8 | 17.2 ± 0.9 | 14.5 ± 0.7 | 15.6 ± 1.8 |
| Heart rate, beats/min | 341.6 ± 10.3 | 356.8 ± 14.5 | 345.1 ± 7.8 | 330.4 ± 17.8 |
| Developed pressure, mmHg | 80.3 ± 4.2 | 81.2 ± 4.8 | 83.3 ± 3.3 | 97.1 ± 6.2* |
Values are means ± SE. WT, wild type; KO, knockout; DKO, double KO. All parameters were collected after 30 min of equilibration in a Langendorff preparation.
*
Significantly different compared with WT hearts.