Table 1.
Effects of 2-wk hypoxic exposure (10% O2, 1 atm) on body weight, left ventricular and septal weight, and right ventricular weight of wild-type and DnTGFβRII mice
| Strain | Treatment (n) | BW, g | (LV+S)/BW, mg/g | RV/BW, mg/g | RV/(LV+S) | Hct, % |
|---|---|---|---|---|---|---|
| Wild-type | Air (9) | 25.3 ± 1.0 | 3.24 ± 0.06 | 0.74 ± 0.03 | 0.23 ± 0.01 | 45 ± 1 |
| Wild-type | Hypoxia (9) | 20.1 ± 1.0* | 3.77 ± 0.21* | 1.42 ± 0.06* | 0.38 ± 0.02* | 66 ± 1* |
| DnTGFβRII | Air (6) | 23.3 ± 0.7 | 3.73 ± 0.09# | 0.88 ± 0.03 | 0.24 ± 0.01 | 47 ± 1 |
| DnTGFβRII | Hypoxia (5) | 23.2 ± 0.6# | 3.72 ± 0.11 | 0.97 ± 0.03† | 0.26 ± 0.01† | 60 ± 1*† |
Results are means ± SE, n = number of mice.
*
P < 0.05 vs. respective air control groups;
†
P < 0.05 vs. respective wild-type groups. DnTGFβRII, dominant-negative transforming growth factor-β receptor type II; BW, body weight; LV + S, left ventricular and septal weight; RV, right ventricular weight; Hct, hematocrit.