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. 2011 Aug 17;301(6):F1251–F1259. doi: 10.1152/ajprenal.00404.2011

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Copyright © 2011 the American Physiological Society

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Fig. 5. — Effect of acute urea loading on urinary concentrating ability and renal handling of urea. Three hundred micromoles of urea were injected (ip) just after the first 2-h urine collection (time 0). A: urinary osmolality (U_osm). B: urinary output. C: urinary urea concentration (U_urea). D: urea excretion (excr.). E: nonurea solute concentration (U_{non-urea solutes}). F: excretion of non-urea solutes. Values are means ± SE; n = 6. *P < 0.01 compared with wild-type mice. #P < 0.01 compared with UT-B knockout mice.