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Coronary blood flow responses to 2-MeS-ADP (A, n = 3) and ATP (B, n = 7). Coronary vasodilation induced by 2-MeS-ADP (plasma concentration ∼10 μM) was markedly attenuated by MRS-2179 (0.5 mg/min ic) or l-NAME (150 μg/min ic). ATP-induced coronary vasodilation was attenuated by MRS-2179. Values are means ± SE. *P < 0.05 vs. control.
