1a |
Was a well-defined question posed in an answerable form? |
1b |
Was a viewpoint for the analysis stated and was the study placed in any particular decision-making context? |
Patient selectionb
|
2a |
Were the eligibility criteria specified? |
2b |
Was a method of randomization used to allocate the patients? |
Interventionb
|
3a |
Were index and control interventions explicitly described? |
3b |
Was the compliance acceptable in all groups? |
Outcome measurement—costsa
|
4a |
Were all the important and relevant costs and consequences identified? |
4b |
Were costs and consequences measured accurately in appropriate physical units? |
4c |
Were costs and consequences valued credibly? |
Outcome measurement—effectb
|
5a |
Was the outcome assessor blinded to the intervention? |
5b |
Were the outcome measures relevant? |
5c |
Was the withdrawal/dropout rate described and acceptable? |
Economic methodologya
|
6a |
Were costs and consequences adjusted for differential timing? |
6b |
Was an incremental analysis of costs and consequences of alternatives performed? |
6c |
Was allowance made for uncertainty in the estimates of costs and consequences? |
6d |
Did the presentation and discussion of the study results include all issues of concern to users? |
Statisticsb,c
|
7a |
Was the sample size for each group described and discussed in relation to power considerations (if not calculations)? |
7b |
Did the analysis include the intention-to-treat analysis? |
7c |
Were the synthesis of costs and benefits reported and if so, were measures of variability presented accordingly for the primary outcome measures? |