Figure 1.

dyb-1 encodes a homolog of mammalian dystrobrevins. Shown is the alignment of predicted amino acid sequences of DYB-1, human αDB1 (accession number NM_001390), and human βDB (accession number AF022728). Positions of molecular lesions of three dyb-1 alleles are indicated. Two alleles have mutations leading to premature stop codon (marked by *) and one allele (marked by an arrow) disrupts the splice acceptor site of the fourth intron, leading to the removal of exon 5 and a frame shift after Y171, which was shortly followed by a stop codon.