Table 1.
Top 50 genes preferentially overexpressed in short-term cultured cells from TMZ resistant GBM xenografts
| Rank | Cytoband | Gene Symbol |
Mean difference (log2) |
Ratio of means |
t-statistic | p-value |
|---|---|---|---|---|---|---|
| 1 | (5q32) | CD74 | 2.79663 | 6.94815 | 23.492 | < 0.0001 |
| 2 | (6p21.3) | HLA-DRB5 | 2.85072 | 7.21358 | 22.644 | < 0.0001 |
| 3 | (8p21) | NEFL | 1.17896 | 2.26413 | 20.054 | < 0.0001 |
| 4 | (15q13-q14) | SGNE1 | 1.27149 | 2.41411 | 19.233 | < 0.0001 |
| 5 | (6p21.2) | DAAM2 | 0.72751 | 1.65578 | 18.995 | < 0.0001 |
| 6 | (8p21) | NEFL | 1.13968 | 2.20333 | 17.16 | < 0.0001 |
| 7 | (6p21.3) | HLA-DRB1 | 3.52285 | 11.4943 | 16.573 | < 0.0001 |
| 8 | (7p12-p14) | STK17A | 0.9058 | 1.87358 | 16.047 | < 0.0001 |
| 9 | (6p21.3) | HLA-DRB1 | 3.01361 | 8.07584 | 15.383 | < 0.0001 |
| 10 | (Xq28) | L1CAM | 1.01344 | 2.01872 | 15.162 | < 0.0001 |
| 11 | (6p21.3) | IER3 | 2.28077 | 4.85938 | 13.452 | < 0.0001 |
| 12 | (6p21.3) | HLA-DQB1 | 0.9112 | 1.88061 | 13.054 | < 0.0001 |
| 13 | (1q24) | PRRX1 | 1.81618 | 3.52147 | 12.681 | < 0.0001 |
| 14 | (6p21.3) | HLA-DPB1 | 1.20809 | 2.31031 | 12.658 | < 0.0001 |
| 15 | (3p21-p14) | WNT5A | 0.73596 | 1.66551 | 12.586 | < 0.0001 |
| 16 | (6p21.3) | HLA-DRB4 | 1.98187 | 3.95004 | 12.402 | < 0.0001 |
| 17 | (6p21.3) | HLA-DRA | 3.08406 | 8.47999 | 12.29 | < 0.0001 |
| 18 | (6p21.3) | HLA-DRA | 3.54244 | 11.6515 | 12.252 | < 0.0001 |
| 19 | (2p14) | C2orf32 | 0.5908 | 1.50609 | 11.768 | < 0.0001 |
| 20 | (18p11.2) | PTPRM | 0.68664 | 1.60953 | 11.666 | < 0.0001 |
| 21 | (7q32-q35) | FLNC | 0.69961 | 1.62407 | 11.445 | < 0.0001 |
| 22 | (6p23) | RNF182 | 0.45141 | 1.36737 | 11.306 | < 0.0001 |
| 23 | (13q12.3) | LOC283537 | 0.3805 | 1.30179 | 11.24 | < 0.0001 |
| 24 | (6p21.3) | HLA-DPA1 | 1.9834 | 3.95425 | 11.131 | < 0.0001 |
| 25 | (5q34) | DUSP1 | 0.8521 | 1.80512 | 11.122 | < 0.0001 |
| 26 | (6p21.3) | HLA-DQB1 | 1.013 | 2.0181 | 10.946 | < 0.0001 |
| 27 | (5q32) | CD74 | 0.55819 | 1.47242 | 10.876 | < 0.0001 |
| 28 | (7q21-q31) | SEMA3C | 0.59447 | 1.50992 | 10.85 | < 0.0001 |
| 29 | (Xp22.1) | SAT | 2.11197 | 4.3228 | 10.75 | < 0.0001 |
| 30 | (1q24) | PRRX1 | 0.68108 | 1.60334 | 10.732 | < 0.0001 |
| 31 | (19q12) | ZNF537 | 0.45421 | 1.37003 | 10.653 | < 0.0001 |
| 32 | (2p22-p21) | LTBP1 | 0.58538 | 1.50044 | 10.433 | < 0.0001 |
| 33 | --- | NA | 0.95214 | 1.93474 | 10.408 | < 0.0001 |
| 34 | (6p21.3) | HLA-DQB1 | 0.70381 | 1.6288 | 10.23 | < 0.0001 |
| 35 | --- | NA | 0.9038 | 1.87099 | 10.136 | < 0.0001 |
| 36 | (16q11.2) | DNAJA2 | 0.37493 | 1.29678 | 10.07 | < 0.0001 |
| 37 | (6p21.3) | HLA-DPA1 | 3.05706 | 8.32275 | 10.028 | < 0.0001 |
| 38 | (7p12-p14) | STK17A | 1.04624 | 2.06514 | 9.91 | < 0.0001 |
| 39 | (6p21.3) | HLA-DQB1 | 0.32749 | 1.25482 | 9.839 | < 0.0001 |
| 40 | (6p21.3) | HLA-DQB1 | 0.61589 | 1.5325 | 9.794 | < 0.0001 |
| 41 | (17q25.3) | SYNGR2 | 0.46094 | 1.37643 | 9.712 | < 0.0001 |
| 42 | (11q13) | FOSL1 | 0.36663 | 1.28933 | 9.697 | < 0.0001 |
| 43 | (2q37.2) | SH3BP4 | 1.84982 | 3.60454 | 9.564 | < 0.0001 |
| 44 | (Xp22.1) | SAT | 1.39986 | 2.63876 | 9.539 | < 0.0001 |
| 45 | (4p16) | CTBP1 | 0.46968 | 1.38481 | 9.536 | < 0.0001 |
| 46 | (14q31) | NRXN3 | 0.81206 | 1.75572 | 9.394 | < 0.0001 |
| 47 | --- | ALS2CR4 | 0.33487 | 1.26127 | 9.351 | < 0.0001 |
| 48 | (10q26) | MGMT | 0.46494 | 1.38026 | 9.238 | < 0.0001 |
| 49 | (2p12) | POLE4 | 0.50419 | 1.41833 | 9.213 | < 0.0001 |
| 50 | (2p13) | TGFA | 0.80093 | 1.74222 | 9.193 | < 0.0001 |
Shown in bold are probes for CD74, which is further investigated in this study