Table IV.

A: Impact of treatment on different outcomes by risk
Event	Treatment (UC vs. ET)	Risk	Interaction p-values
All-cause mortality or all-cause hospitalization (primary end point)	0.41	<0.01	0.54
Cardiovascular mortality or CV hospitalization	0.20	<0.01	0.69
Cardiovascular mortality or HF hospitalization	0.06	<0.01	0.50
All-cause mortality	0.92	<0.01	0.63

B: Impact of treatment on different outcomes by NYHA class
Event	Treatment (UC vs. ET)	NYHA Class (III/IV vs. II)	Interaction
All-cause mortality or all-cause hospitalization (primary end point)	0.42	<0.01	0.29
Cardiovascular mortality or CV hospitalization	0.33	<0.01	0.52
Cardiovascular mortality or HF hospitalization	0.32	<0.01	0.37
All-cause mortality	0.73	<0.01	0.27

C. Impact of treatment on different outcomes by CPX duration
Event	Treatment (UC vs. ET)	CPX Duration	Interaction
All-cause mortality or all-cause hospitalization (primary end point)	<0.01	<0.01	0.03
Cardiovascular mortality or CV hospitalization	0.20	<0.01	0.50
Cardiovascular mortality or HF hospitalization	0.38	<0.01	0.94
All-cause mortality	0.55	<0.01	0.62