. Author manuscript; available in PMC: 2012 Jan 1.

Published in final edited form as: Curr Drug Metab. 2011 Jan;12(1):51–56. doi: 10.2174/138920011794520008

Table 1.

Pharmacogenetics of Antimalarial Drugs (Modified From Reference): [48]

Drug	Mechanism of Metabolism/Transport	Single Nucleotide Polymorphisms
Amodiaquine	CYP2C8, −1A1, −1B1	CYP2C83, CYP2C8**2
Artemisinins	CYP2A6, −3A4/5, −2B6 (secondary), UGT1A9, −2B7, −3A4 and MDR1 inducer	--
Chloroquine	CYP2C8, −3A4/5, −2D6, MDR1	--
Chlorproguanil/proguanil	CYP2C19, −3A4	CYP2C19
Mefloquine	CYP3A4, MDR1, BCRP	ABCB1 1236, −2677, −3435, ABCG2
Primaquine	CYP1A2, −3A4	G6PD
Quinine	CYP3A4/5, −2C9, MDR1	CYP3A5*3