Fig. 10.

While acute exposure to H₂O₂ or Fe²⁺-H₂O₂ increases lipid peroxidation in cortico-hippocampal brain slices, only Fe²⁺-H₂O₂ increases lipid peroxidation in brain stem slices. A: exposure to H₂O₂ (2.2 mM 600s; n = homogenates from 6 slices) or Fe²⁺-H₂O₂ (100 μM-2.2 mM 600s; n = homogenates from 7 slices) increased lipid peroxidation in cortico-hippocampal brain slices compared with time-matched untreated controls (n = homogenates from 7 slices). B: while exposure to Fe²⁺-H₂O₂ (100 μM-2.2 mM 600 s; n = homogenates from 5 slices) significantly increased lipid peroxidation, no significant increase (N.S.) in lipid peroxidation was observed during exposure to H₂O₂ (2.2 mM 600 s; n = homogenates from 6 slices) compared with time-matched untreated controls (n = homogenates from 6 slices). **P < 0.01, ***P < 0.001.