Table 2. Cancer susceptibility and principal features of NER–deficient mice.

Mouse Model	Cancer susceptibility			Median survival	Principal features	References
	untreated	UV-induced	DMBA-induced
Xpa−/−	+/−	++	++	trend of reduced survival	normal weight, photosensitive skin and eyes, increased mutation frequencies, impaired spermatogenesis	[41], [43], [44], [52], [53], [56]
Xpc−/−	+/−	++	+	mildly reduced	normal weight, photosensitive skin and eyes, increased mutation frequencies	[43], [47], [52], [56]
Csa−/−	−	+	ND	ND	mildly reduced weight, photosensitive skin and eyes, retinal photoreceptor degeneration, increased vulnerability to γ-irradiation	[20], [46], [48], [54], [55]
Csb−/−	−	+	+	normal	mildly reduced weight, photosensitive skin and eyes, no changes in mutation frequency, retinal photoreceptor degeneration, increased vulnerability to γ-irradiation	[20], [45], [48], [54], [55]
XpdXPCS	+	++	++	mildly reduced	mildly reduced weight, smaller testis	[28], [49]
XpdTTD	−	+	+	mildly reduced	reduced weight, TTD-like brittle hair, mild osteoporosis, signs of accelerated aging, anaemia	[50], [51], [53]