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. 2011 Dec 8;6(12):e28486. doi: 10.1371/journal.pone.0028486

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Qi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Levels of miR-122 (A), miR-222 (B), miR-223 (C) and miR-21 (D) were measured in serum of 48 HCC patients (n = 48), HBV patients without HCC (n = 48) and healthy subjects (n = 24) by RT-qPCR. Levels of miR-122 were significantly higher in HCC patients than disease controls (p<0.05) or healthy controls (p<0.001). Although levels of miR-222 and miR-223 were also significantly elevated in HCC patients than in healthy controls (p<0.05), no significant difference was observed for these two miRNAs between HBV subjects with and without HCC (p>0.05). Levels of miR-21 were reduced in HCC patients than in healthy controls (p<0.05), no significant difference was observed for miR-21 between HBV subjects with and without HCC (p>0.05).