Table 1. Summary of clinical details of subjects used for miRNA analysis.
| Healthy control(n = 34) | HBV patientswithout HCC(n = 48) | HBV patientswith HCC(n = 70) | |
| Age, median, y | 38 | 45 | 49 |
| Men, n (%) | 24 (70.8) | 37 (77.1) | 55 (78.6) |
| Laboratory values | |||
| mean (SD) | |||
| Total bilirubinb, µmol/L | 14.1 (5.3) | 14.9 (6.2) | 19.2 (10.3) |
| Albumina, g/L | 48.6 (2.9) | 47.3 (3.5) | 40.1 (3.9) |
| Alanine aminotransferaseb, U/L | 20.3 (12.2) | 26.2 (10.6) | 116.6 (257.6) |
| Tumor number (n = 70) n (%) | |||
| Single | 48 (68.6) | ||
| Multiple | 22 (31.4) | ||
| Tumor size (n = 70) n (%) | |||
| <5 cm | 17 (24.3) | ||
| ≥5 cm | 53 (75.7) | ||
| Tumor grade (n = 65) n (%) | |||
| I and II | 14 (21.5) | ||
| III and IV | 51 (78.5) | ||
| Tumor stage (n = 70) n (%)* | |||
| I | 8 (11.4) | ||
| II | 36 (51.4) | ||
| III | 20 (28.6) | ||
| IV | 6 (8.6) | ||
| Hepatic cirrhosis status (n = 68) n (%) | |||
| Positive | 51 (75.0) | ||
| Negative | 17 (25.0) | ||
| Child-pugh grade (n = 70) n (%) | |||
| A | 59 (84.3) | ||
| B | 8 (11.4) | ||
| C | 3 (4.3) |
a
, significant difference exists between three cohorts (p<0.001).
b
, significant difference exists between HCC group and non-HCC groups (p<0.001).
*Tumor stage was obtained according to the TNM criteria.