. 2011 Dec 8;6(12):e28794. doi: 10.1371/journal.pone.0028794

Table 1. Brain regions with functional connectivity changes with the left amygdala in common between schizophrenic patients and their parents.

Regions	Side	BA	Cluster-size (k)^a	Coordinates of geometric centers^b	Mean connectivity z values
					SZ	HC1	PA	HC2
Decreased negative connectivity
Middle frontal cortex/Pars triangularis	R	46/45/9	89	38 38 30	−0.11(0.15)^c ^*	−0.24(0.15)^*	−0.11(0.15)^*	−0.24(0.14)^*
Middle frontal/Superior frontal cortex	R	8	29	28 10 56	−0.12(0.14)^*	−0.23(0.10)^*	−0.10(0.17)^*	−0.21(0.16)^*
Precuneus	R	7	28	10 −66 48	−0.08(0.20)^*	−0.19(0.11)^*	−0.12(0.14)^*	−0.21(0.11)^*
Middle frontal/Superior frontal cortex	L	6/8	17	−27 5 60	−0.05(0.14)	−0.16(0.14)^*	−0.10(0.19)^*	−0.22(0.21)^*
Angular/Inferior parietal cortex	R	40/39	14	40 −56 44	−0.10(0.20)^*	−0.22(0.13)^*	−0.14(0.16)^*	−0.23(0.14)^*
Precuneus	R	NA	11	16 −59 41	−0.03(0.21)	−0.15(0.12)^*	−0.08(0.18)^*	−0.18(0.13)^*
Decreased positive connectivity
Medial orbitofrontal cortex	L	10/11	22	−10 44 −10	0.01(0.18)	0.15(0.15)^*	0.09(0.17)^*	0.21(0.18)^*
Inferior orbitofrontal cortex	L	11/48/38	21	−23 14 −22	−0.004(0.14)	0.21(0.20)^*	0.08(0.19)^*	0.22(0.13)^*
Others ^d
Parahippocampus/Lingual cortex	L	37	12	−28 −43 −6	0.04(0.17)	0.17(0.16)^*	0.16(0.21)^*	0.04(0.14)
Inferior orbitofrontal cortex/Pars triangularis	L	47/45	11	−46 26 −2	0.01(0.19)	0.13(0.16)^*	0.14(0.18)^*	0.0040(0.24)

k = number of voxels in the particular cluster, only cluster-size (k)>10 voxels were listed.

In Montreal Neurological Institute (MNI) space.

Mean (standard deviation).

The changed patterns of functional connectivity were inconsistent between schizophrenic patients and their unaffected parents.

*indicates a significant functional connectivity (p<0.05) with the left amygdala within groups.

The brain imaging results were labeled with the Automated Anatomical Labeling (AAL) software (82) in combination with the Brodmann templates implemented in MRIcroN software (http://www.cabiatl.com/mricro/mricron). SZ, schizophrenic patients; HC1, healthy controls for schizophrenic patients; PA, parents of schizophrenic patients; HC2, healthy controls for parents; BA, Brodmann area; NA, nonapplicable.