Skip to main content
. Author manuscript; available in PMC: 2012 Dec 15.
Published in final edited form as: J Neuroimmunol. 2011 Nov 17;240-241:65–73. doi: 10.1016/j.jneuroim.2011.10.010

Figure 5. Effects of Treg adoptive transfer on the splenic population of FOXP3+ T cells, and potency of GM-CSF-induced Tregs suppression of the AChR-stimulated T cell proliferative response.

Figure 5

The percentage of FOXP3+ regulatory T cells in splenocytes are shown for the four experimental groups (A). No significant difference is apparent in the expansion of Foxp3-expressing splenocytes in mice receiving CD4+CD25+ cells. Despite this, GM-CSF-induced Tregs suppressed the AChR-induced proliferation of responder T cells more potently compared to Tregs from PBS-treated animals; GM-CSF-induced Tregs maintain their suppressive potency at lower Treg/Teff ratios (B). Results are representative of three separate experiments with each column representing the mean ± SEM (*p < 0.05).