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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Prostate. 2011 Jan 12;71(11):1198–1209. doi: 10.1002/pros.21335

Figure 5. Nodal Antagonizes Androgen Receptor Signaling.

Figure 5

(A) LNCaP cells transfected with 10–250 ng of Nodal and treated with 1 nM R1881. PSA luciferase activity relative to Renilla is significantly reduced by 250 ng of Nodal (Two way Anova with Tukey’s posthoc analysis, n=3, *P<0.05). (B) Real-time PCR of PSA, KLK2, TMPRSS2, and NKX3.1 which were all significantly down-regulated in LNCaP cells stably transfected with Nodal compared with the vector control (t test, n=3, **P<0.01, ***P<0.001).