Figure 3.

Spatiotemporal pattern of amyloid plaque deposition according to Thal et al. (2002). Coronal (A), axial (B), and sagittal (C) views of the brain. The five Thal stages of amyloid deposition are here summarized in three stages. Amyloid deposits accumulate first in isocortical areas (stage 1 or isocortical, in red), followed by limbic and allocortical structures (stage 2 or limbic, in orange), and in a later stage, by subcortical structures including basal ganglia, selected nuclei in diencephalon and brainstem, and the cerebellar cortex (stage 3 or subcortical, in yellow). Amyg = Amygdala; EC = Entorhinal cortex; Hipp = Hippocampus; Cg = Cingulate cortex; Cd = Caudate nucleus; Put = Putamen; Gpe = Globus pallidus externus; Gpi = Globus pallidus internus; Cl = Claustrum; Ins = Insular cortex; Die = Diencephalon; Mid = Midbrain; Med = Medulla oblongata; Cblm = Cerebellum.