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An overview of the study design: in stage 1, we conducted a genome-wide scan, which detected significant association between PD and a two-marker segment (D17S1294–D17S1293) on chromosome 17. In stage 2, we followed up on 17q11.2-q12, which revealed significant association between PD and several markers (D17S1540, D17S1293 and D17S1842) within this region and suggested ACCN1 as a possible candidate gene. In stage 3, we analysed ACCN1 for association with PD, using tag-SNPs.
