Table 1. Alleles and segments in 17q11.2-q12 showing significant association with PD (stage 2).

CLUMP								Fisheŕs exact test				IBD by chance
Single marker					Two markers
Marker	Cases	Controls	T1	T4	Marker	T1	T4	Segment	Cases	Controls	P	(P) IBD0	(P) IBD0−sum
rs28936
G	15 (0.58)	22 (0.26)	0.0030	0.0030	rs28936–rs28935	0.0025	0.0028
A	11 (0.42)	62 (0.74)
rs28935
A	15 (0.58)	74 (0.86)	0.0010	0.0010	rs28935–rs62068265	0.0033	0.0033	rs28935–rs62068265	9/26	12/86	0.0410	2.587 × 10−11	5.493 × 10−9
G	11 (0.42)	12 (0.14)
rs62068265
G	24 (0.92)	84 (0.98)	0.1400	0.0140	rs62068265–rs28933	0.0006	0.0002	rs62068265–rs28933	15/26	18/84	0.0011	1.230 × 10−22	2.673 × 10−19
C	2 (0.08)	2 (0.02)
rs28933
A	15 (0.58)	18 (0.21)	0.0010	0.0010	rs28933–D17S1540	0.0007	0.0008	rs28933–D17S1540	8/18	4/72	0.0002	3.521 × 10−11	5.615 × 10−9
G	11 (0.42)	66 (0.79)
D17S1540
a	9 (0.35)	9 (0.11)	0.0180	0.0200
	17 (0.65)	71 (0.89)
D17S1293
a	7 (0.27)	9 (0.10)	0.1480	0.1300	D17S1293–D17S1842	0.0070	0.0070	D17S1293–D17S1842	4/18	1/86	0.0030	1.179 × 10−4	1.03 × 10−2
	19 (0.63)	77 (0.90)
D17S1842
a	16 (0.62)	60 (0.70)	0.0670	0.0590				rs28936–rs28935–rs62068265	8/20	9/76	0.0069	9.940 × 10−11	1.541 × 10−8
	10 (0.48)	26 (030)						rs28935–rs62068265–rs28933	8/18	5/78	0.0003	3.521 × 10−11	5.501 × 10−9
								rs62068265–rs28933–D17S1540	8/20	4/70	0.0005	9.940 × 10−11	1.541 × 10−8

Empirical CLUMP (T1 and T4 test statistics) for single- and two-marker analyses.

Fisher's exact test for specific haplotypes/segments (alleles not shown).

IBD_0−sum shows the same probability summed over all 29 markers in 17q11.2-q12.

^aThe allele frequency is given for the allele showing the most skewed distribution against all other alleles.